plastin-2; L-plastin; lymphocyte cytosolic protein 1; LCP-1; LC64P (LCP1 PLS2)

Function

• actin-binding protein found in intestinal microvilli, hair cell stereocilia, & fibroblast filopodia
• phosphorylated

Structure

• the N-terminus is blocked
• monomer
• contains 2 actin-binding domains
• contains 4 CH (calponin-homology) domains
• contains 2 EF-hand domains

Compartment

cytoplasm

Expression

• restricted to spleen & other lymph node-containing organs
• expressed in neutrophils, monocytes, B lymphocytes, & myeloid cells

More general terms

• plastin or fimbrin

Database

• UniProt: http://www.uniprot.org/uniprot/P13796.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3936
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3936
• OMIM: https://mirror.omim.org/entry/153430