lymphocyte antigen 86; Ly-86; protein MD-1 (LY86, MD1)

Function

• cooperates with CD180 & TLR4 to mediate innate immune response to bacterial lipopolysaccharide (LPS) & cytokine production (putative)
• role in efficient CD180 cell surface expression
• M-shaped tetramer of two CD180-LY86 heterodimers

Compartment

• secreted, extracellular space
• associated with CD180 at the cell surface

Expression

• expressed in B-cells, monocytes & in pallatine tonsil

Pathology

• down-regulated in monocytes by the cell-wall fraction of Mycobacterium bovis

More general terms

• glycoprotein
• secreted protein
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9450
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9450
• OMIM: https://mirror.omim.org/entry/605241
• UniProt: http://www.uniprot.org/uniprot/O95711.html