pyroglutamyl-peptidase 1; pyrrolidone-carboxylate peptidase; 5-oxoprolyl-peptidase; PGP-I (PGPEP1, PGPI)

Function

• removes 5-oxoproline from various penultimate amino acid residues except L-proline (putative)
• release of an N-terminal pyroglutamyl group from a polypeptide, the 2nd amino acid generally not being Pro

Inhibition:

• inhibited by transition metal ions including Ni+2, Zn+2, & Cu+2 & by sulfhydryl-blocking agents

Structure

• monomer
• belongs to the peptidase C15 family

Compartment

cytoplasm

Alternative splicing

named isoforms=2

More general terms

• peptidase; peptide hydrolase
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54858
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54858
• OMIM: https://mirror.omim.org/entry/610694
• UniProt: http://www.uniprot.org/uniprot/Q9NXJ5.html