carcinoembryonic antigen-related cell adhesion molecule 16; carcinoembryonic antigen-like 2 (CEACAM16, CEAL2)

Function

• may play a role in maintaining integrity of the tectorial membrane
• monomer, homodimer, tetramer
• interacts with TECTA

Structure

• belongs to the immunoglobulin superfamily, CEA family
• contains 2 Ig-like C2-type domain (immunoglobulin-like)

Compartment

• secreted
• localizes to the tip of cochlear outer hair cells & to the tectorial membrane

Pathology

• defects in CEACAM16 are the cause of deafness autosomal dominant type 4B

More general terms

• glycoprotein
• membrane protein
• human longevity protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q2WEN9.html