tectorin-alpha (TECTA)

Function

• one of the major non-collagenous components of the tectorial membrane
• may form homomeric filament after self-association or heteromeric filament after association with beta-tectorin

Compartment

• cell membrane, lipid-anchor, GPI-anchor
• targeted to the apical surface of the inner ear epithelia & proteolytically released into the extracellular compartment

Pathology

• defects in TECTA are the cause of autosomal dominant non-syndromic sensorineural deafness 8
• defects in TECTA are the cause of autosomal dominant non-syndromic sensorineural deafness 12
• defects in TECTA are the cause of autosomal recessive non-syndromic sensorineural deafness 21

More general terms

• tectorin

Database

• OMIM: https://mirror.omim.org/entry/601543
• OMIM: https://mirror.omim.org/entry/601842
• OMIM: https://mirror.omim.org/entry/602574
• OMIM: https://mirror.omim.org/entry/603629
• UniProt: http://www.uniprot.org/uniprot/O75443.html