carcinoembryonic antigen (CEA) family protein or carcinoembryonic antigen-related cell adhesion molecule (CEACAM)

Function

• tumor-associated oncofetal antigen
• CEA may be the fetal counterpart of albumin

Structure

• collectively CEA is a heterogenous group of glycoproteins with at least 13 different genetically-controlled forms
• CEA contains about 800 amino acid residues
• carbohydrate content is 50-85%

Expression

• observed in embryonic & fetal tissues

Pathology

• CEAD-14 monoclonal antibody recognizes only a subset of breast carcinomas, mostly high grade.

More general terms

• adhesion receptor
• fetal protein
• tumor marker

More specific terms

• carcinoembryonic antigen-related cell adhesion molecule 19; carcinoembryonic antigen-like 1 (CEACAM19, CEAL1, UNQ2973/PRO7436)
• carcinoembryonic antigen-related cell adhesion molecule 1; biliary glycoprotein 1; BGP-1; CD66a (CEACAM1, BGP, BGP1)
• carcinoembryonic antigen-related cell adhesion molecule 20 (CEACAM20)
• carcinoembryonic antigen-related cell adhesion molecule 4 (carcinoembryonic antigen CGM7, non-specific cross-reacting antigen W236, CEACAM4, CGM7)
• carcinoembryonic antigen-related cell adhesion molecule 6; normal cross-reacting antigen; non-specific crossreacting antigen; CD66c (CEACAM6 NCA)
• carcinoembryonic antigen-related cell adhesion molecule 7; carcinoembryonic antigen CGM2 (CEACAM7, CGM2)
• CD66b; carcinoembryonic antigen-related cell adhesion molecule 8; carcinoembryonic antigen CGM6; non-specific cross-reacting antigen NCA-95; CD67 antigen (CEACAM8, CGM6)
• CD66D; carcinoembryonic antigen-related cell adhesion molecule 3; carcinoembryonic antigen CGM1 (CEACAM3, CD66D, CGM1)
• CD66e; carcinoembryonic antigen-related cell adhesion molecule 5; carcinoembryonic antigen; CEA; meconium antigen 100; CD66e (CEACAM5, CEA)

Additional terms

• carcinoembryonic antigen (CEA) in serum/plasma

Database

• OMIM: https://mirror.omim.org/entry/114890