CD66b; carcinoembryonic antigen-related cell adhesion molecule 8; carcinoembryonic antigen CGM6; non-specific cross-reacting antigen NCA-95; CD67 antigen (CEACAM8, CGM6)

Function

• can activate neutrophils
• may regulate CD11/CD18 activity

Structure

• belongs to the immunoglobulin superfamily, CEA family
• contains 2 Ig-like C2-type domain (immunoglobulin-like)
• contains 1 Ig-like V-type domain (immunoglobulin-like)

Compartment

cell membrane; lipid-anchor, GPI-anchor

Expression

bone marrow

Pathology

• expressed in leukocytes of chronic myelogenous leukemia

More general terms

• CD antigen
• glypiated protein
• carcinoembryonic antigen (CEA) family

Database

• UniProt: http://www.uniprot.org/uniprot/P31997.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1088
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1088
• OMIM: https://mirror.omim.org/entry/114890