CD66D; carcinoembryonic antigen-related cell adhesion molecule 3; carcinoembryonic antigen CGM1 (CEACAM3, CD66D, CGM1)

Function

• major granulocyte receptor mediating recognition & efficient opsonin-independent phagocytosis of CEACAM- binding microorganisms, including Neissiria, Moxarella & haemophilus species, thus playing an important role in clearance of pathogens by the innate immune system
• can activate neutrophils
• may regulate CD11/CD18 activity in neutrophils
• responsible for RAC1 stimulation in the course of pathogen phagocytosis
• Tyr-phosphorylated in response to microbial binding
• Tyr-230 & Tyr-241 are both required for phosphorylation to be detected
• interacts with S100A9/calprotectin, Ca+2-dependent, but independent of CEACAM3 phosphorylation

Structure

• the cytosolic domain is involved in S100A9 interaction
• belongs to the immunoglobulin superfamily, CEA family
• contains 1 Ig-like V-type domain (immunoglobulin-like)

Compartment

membrane

Alternative splicing

named isoforms=3

Expression

• granulocytes
• CGM1a, the predominant CGM1 transcript, is granulocyte-specific
• not detected out of the granulocytic lineage

Pathology

• receptor for Neisseria gonorrhea & N. meningitidis

Notes

this is not the ortholog of rat CEACAM3

More general terms

• CD antigen
• carcinoembryonic antigen (CEA) family

Database

• UniProt: http://www.uniprot.org/uniprot/P40198.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1084
• OMIM: https://mirror.omim.org/entry/609142