calprotectin complex (S100A8/A9)
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Function
- extracellular calprotectin binds to target cells & promotes apoptosis
- interacts with ANXA6 & associates with tubulin filaments in activated monocytes
Structure
- subunits: S100A8, S100A9; heterotetramer, 2 copies of each
Compartment
- extracellular
Pathology
- calprotectin is shed in the stool of patients with inflammatory bowel disease (see calprotectin in stool)
- may be a biomarker for atherosclerotic cardiovascular disease[2]
- mechanistically informed
- calprotectin in serum is elevated in patients with systemic lupus erythematosus & cognitive impairment[3]
- inverse relationship of calprotectin levels with cognitive performance.
Laboratory
- serum S100A8/A9 (calprotectin in serum)
- may be useful as a marker of inflammation
- diagnosis of acute appendicitis
- associated with cognitive impairment in patients with systemic lupus erythematosus
- may be useful as a marker of inflammation
More general terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P05109.html
- ↑ 2.0 2.1 Zuo Y, NaveenKumar SK, Navaz S et al Epidemiological and Translational Study of Calprotectin and Atherosclerotic Cardiovascular Disease. JAMA Cardiol. 2025 May 7:e250945. PMID: https://pubmed.ncbi.nlm.nih.gov/40332890 https://jamanetwork.com/journals/jamacardiology/fullarticle/2833589
- ↑ 3.0 3.1 Harris S Lupus and the Brain Study links key protein and cognitive function. MedPage Today. January 27, 2026. https://www.medpagetoday.com/reading-room/acrr/lupus/119584
Munoz-Grajales C, Barraclough ML, Diaz-Martinez JP et al Association of Elevated Serum S100A8/A9 Levels and Cognitive Impairment in Patients With Systemic Lupus Erythematosus. Arthritis Care & Research. 2025 Nov;77(11):1303-1312 PMID: https://pubmed.ncbi.nlm.nih.gov/40386900 PMCID: PMC12550649 Free PMC article. https://pmc.ncbi.nlm.nih.gov/articles/PMC12550649/ https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/acr.25575