calprotectin complex (S100A8/A9)
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Function
- extracellular calprotectin binds to target cells & promotes apoptosis
- interacts with ANXA6 & associates with tubulin filaments in activated monocytes
Structure
- subunits: S100A8, S100A9; heterotetramer, 2 copies of each
Compartment
- extracellular
Pathology
- calprotectin is shed in the stool of patients with inflammatory bowel disease (see calprotectin in stool)
Laboratory
- serum S100A8/A9 may be useful as a marker of inflammation & in the diagnosis of acute appendicitis