calprotectin in stool (S100A8/A9 in stool)
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Introduction
also see serum S100A8/A9 (calprotectin in serum)
Indications
- diagnosis of inflammatory bowel disease (IBD)
- index of suspicion not high
- cost-effective when the pretest probability of IBD is <= 75% (adults) & <= 65% (children)[1]
- monitoring of ulcerative colitis (or other colitis)[3]
- rising levels warrant endoscopic evaluation
- can be used to monitor for postoperative recurrences
Reference interval
- 50 ug/g
Clinical significance
- calprotectin is shed in the stool of patients with inflammatory bowel disease
More general terms
Additional terms
- calprotectin complex (S100A8/A9)
- protein S100-A8
- protein S100-A9; S100 Ca+2-binding protein A9; calgranulin-B; migration inhibitory factor-related protein 14; MRP-14; p14; Leukocyte L1 complex heavy chain; calprotectin L1H subunit (S100A9, CAGB, CFAG, MRP14)
References
- ↑ 1.0 1.1 Calprotectin, Fecal Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0092303.jsp
Calprotectin, Fecal https://arupconsult.com/ati/calprotectin-fecal - ↑ Yang Z et al. Effectiveness and cost-effectiveness of measuring fecal calprotectin in diagnosis of inflammatory bowel disease in adults and children. Clin Gastroenterol Hepatol 2014 Feb; 12:253 PMID: https://www.ncbi.nlm.nih.gov/pubmed/23883663
- ↑ 3.0 3.1 Colombel JF, Narula N, Peyrin-Biroulet L. Management Strategies to Improve Outcomes of Patients with Inflammatory Bowel Diseases. Gastroenterology. 2016 Oct 5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/27720840