annexin A6 (ANXA6, lipocortin-6, chromobindin-20, p67 calelectrin, calphobindin-2)

Function

• may associate with CD21
• may regulate release of Ca+2 from intracellular stores
• phosphorylated in response to growth factor stimulation
• seems to bind one Ca+2 with high affinity

Structure

• a pair of annexin repeats may form one binding site for Ca+2 & phospholipid
• belongs to the annexin family
• contains 8 annexin repeats

Compartment

• cytoplasm (putative), melanosome
• identified by mass spectrometry in melanosome fractions from stage 1 to stage 4

Expression

induced by EBV

More general terms

• lipocortin or calpactin
• annexin

Database

• UniProt: http://www.uniprot.org/uniprot/P08133.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:309
• OMIM: https://mirror.omim.org/entry/114070
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=309