carcinoembryonic antigen-related cell adhesion molecule 1; biliary glycoprotein 1; BGP-1; CD66a (CEACAM1, BGP, BGP1)

Function

• can activate neutrophils
• may regulate CD11/CD18 activity

Structure

• belongs to the immunoglobulin superfamily, CEA family
• contains 3 Ig-like C2-type domain (immunoglobulin-like)
• contains 1 Ig-like V-type domain (immunoglobulin-like)

Compartment

• isoform A: cell membrane; type 1 membrane protein
• isoform B: cell membrane; type 1 membrane protein
• isoform C: cell membrane; type 1 membrane protein
• isoform G: secreted
• isoform H: secreted
• isoform I: secreted

Alternative splicing

named isoforms=7; A,B,C,D,G,H,I

Expression

• granulocytes
• epithelial cells

Pathology

• receptor for Neisseria gonorrhea & N meningitidis
• loss or reduced expression in colorectal carcinoma
• increased serum levels of BGP-1 are found in individuals with from hepatic disorders

More general terms

• CD antigen
• carcinoembryonic antigen (CEA) family

Database

• UniProt: http://www.uniprot.org/uniprot/P13688.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=634
• OMIM: https://mirror.omim.org/entry/109770