neuron navigator 2; helicase APC down-regulated 1; retinoic acid inducible in neuroblastoma 1; steerin-2; unc53H2 (NAV2, HELAD1, KIAA1419, RAINB1, STEERIN2)

Function

• 3' to 5' helicase activity & exonuclease activity
• role in neuronal development, specifically development of sensory organs

Structure

• belongs to the Nav/unc-53 family
• contains 1 CH domain (calponin-homology domain)

Compartment

nucleus

Alternative splicing

• named isoforms=13
• additional isoforms may exist

Expression

• expressed in the brain, kidney liver > thyroid, mammary gland, spinal cord, heart, placenta, lung
• highly expressed in nervous system of developing embryos
• induced by all-trans retinoic acid (atRA)

Pathology

• abundantly expressed in colon cancers

More general terms

• helicase (DNA unwinding protein, DNA untwisting protein)
• exoribonuclease
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=89797
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:89797
• OMIM: https://mirror.omim.org/entry/607026
• UniProt: http://www.uniprot.org/uniprot/Q8IVL1.html