G-protein coupled receptor 27; super conserved receptor expressed in brain 1 (GPR27, SREB1)

Function

• orphan receptor
• possibly, amine-like G-protein coupled receptor

Structure

• belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane; multi-pass membrane protein

Expression

• highly expressed as a 3.0 kb transcript in brain, ovary, testis, heart, prostate & peripheral Leukocytes
• lower levels in pancreas & small intestine
• a 2.3 kb transcript is found in peripheral blood leukocytes
• in brain regions
  • detected as a 3.0 kb transcript in all regions tested
  • highest levels in the caudate nucleus, putamen, hippocampus & subthalamic nucleus
  • lowest expression in the cerebellum

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2850
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2850
• OMIM: https://mirror.omim.org/entry/605187
• UniProt: http://www.uniprot.org/uniprot/Q9NS67.html