homeobox protein MOX-2; growth arrest-specific homeobox protein GAX; mesenchyme homeobox 2; MEOX2; GAX (MOX2)

Function

• role in mesoderm induction & its earliest regional specification, somitogenesis, & myogenic & sclerotomal differentiation
• may have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle
• interacts with RNF10

Structure

• the polyhistidine repeat may act as a targeting signal to nuclear speckles
• contains 1 homeobox DNA-binding domain

Compartment

nucleus, nuclear speckle (putative)

Expression

embryo & placenta

Polymorphism

• poly-His region of MEOX2 is polymorphic & the number of His varies in the population

More general terms

• homeobox protein
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4223
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4223
• OMIM: https://mirror.omim.org/entry/600535
• UniProt: http://www.uniprot.org/uniprot/P50222.html