2-oxoglutarate dehydrogenase, mitochondrial; 2-oxoglutarate dehydrogenase complex component E1; OGDC-E1; alpha-ketoglutarate dehydrogenase (OGDH)

Function

• component of the 2-oxoglutarate dehydrogenase complex
  • the 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA & CO2
  • it contains multiple copies of 3 enzymatic components:
    • 2-oxoglutarate dehydrogenase E1 = this protein
    • dihydrolipoamide succinyltransferase E2
    • lipoamide dehydrogenase E3
• Ca+2 & ADP stimulate activity, whereas ATP & reduce catalytic activity

Cofactor: thiamine pyrophosphate

Structure

• belongs to the alpha-ketoglutarate dehydrogenase family

Compartment

mitochondrial matrix

Alternative splicing

named isoforms=3

Notes

probably insensitive to Ca+2

More general terms

• dehydrogenase
• protein subunit
• phosphoprotein
• Ca+2 binding protein
• human longevity protein

Component of

• alpha-ketoglutarate dehydrogenase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4967
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4967
• OMIM: https://mirror.omim.org/entry/613022
• UniProt: http://www.uniprot.org/uniprot/Q02218.html