alpha-ketoglutarate dehydrogenase

Function

• catalyzes overall conversion of 2-oxoglutarate to succinyl-CoA & CO2
• contains multiple copies of three enzymatic components:
  • 2-oxoglutarate dehydrogenase E1 (DHKTD1)
  • dihydrolipoamide succinyltransferase E2
  • lipoamide dehydrogenase E3

Cofactor: Thiamine pyrophosphate (putative)

More general terms

• multienzyme complex
• ketone oxidoreductase
• dehydrogenase
• citric acid cycle enzyme

Additional terms

• citric acid cycle, Krebs cycle or tricarboxylic acid [TCA] cycle

Database

• OMIM: https://mirror.omim.org/entry/246900