solute carrier family 4 member 4; electrogenic sodium bicarbonate cotransporter 1; sodium bicarbonate cotransporter; Na+/HCO3- cotransporter (SLC4A4, kNBC1, NBC, NBC1, NBCE1)

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Introduction

Electrogenic Na+/HCO3- cotransporter with stoichiometry varying from 1:2 to 1:3. May regulate HCO3- influx/efflux at basolateral membrane of cells & regulate intracellular pH. Defects in SLC4A4 are the cause of renal tubular acidosis 2.

Function

Structure

Compartment

basolateral cell membrane

Alternative splicing

named isoforms=4

Expression

Pathology

More general terms

Additional terms

References

Database