carbonic anhydrase-4 (CA4)

Function

• reversible hydration of CO2
• may stimulate the Na+/bicarbonate transporter activity of SLC4A4
• interacts with SLC4A4
• inhibited by acetazolamide

H2CO3 <--> CO2 + H2O

Cofactor: Zn+2

Structure

belongs to the alpha-carbonic anhydrase family

Compartment

cell membrane, lipid-anchor, GPI-anchor

Expression

• expressed in endothelium of choriocapillaris in eyes (at protein level)

Pathology

• defects in CA4 are the cause of retinitis pigmentosa type 17

More general terms

• carbonic anhydrase (dehydratase)
• glypiated protein

Database

• UniProt: http://www.uniprot.org/uniprot/P22748.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:762
• OMIM: https://mirror.omim.org/entry/114760
• OMIM: https://mirror.omim.org/entry/600852
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=762