carbonic anhydrase-2 (carbonic anhydrase-B, CA2)

Function

• reversible hydration of carbon dioxide interacts with SLC4A4
• interaction with SLC4A7 regulates SLC4A7 transporter activity
• role in osteoclast function & bone resorption

H3CO3 <--> CO2 + H2O

Cofactor: Zn+2

Structure

belongs to the alpha-carbonic anhydrase family

Compartment

cytoplasm

Expression

• only carbonic anhydrase isozyme expressed in kidney
• also expressed in brain & erythrocytes

Pathology

• defects in CA2 are the cause of carbonic anhydrase 2 deficiency

Laboratory

• carbonic anhydrase 2 Ab in serum

More general terms

• carbonic anhydrase (dehydratase)
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/P00918.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:760
• OMIM: https://mirror.omim.org/entry/259730
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=760