pleckstrin homology domain-containing family A member 7; PH domain-containing family A member 7 (PLEKHA7)

Function

• required for adherens junction biogenesis & maintenance
• acts via its interaction with KIAA1543/Nezha, which anchors microtubules at their minus-ends to the adherens junction, & recruits KIFC3 kinesin to junctional site
• interacts with KIAA1543/Nezha & CTNND1

Structure

• contains 1 PH domain
• contains 2 WW domains

Compartment

• cell junction, adherens junction
• cytoplasm, cytoskeleton, centrosome
• localizes to adherens junction, recruited via its interaction with CTNND1

Alternative splicing

named isoforms=3

More general terms

• pleckstrin homology domain containing family
• phosphoprotein
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=144100
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:144100
• OMIM: https://mirror.omim.org/entry/612686
• UniProt: http://www.uniprot.org/uniprot/Q6IQ23.html