cytochrome p450 5A; thromboxane A [TxA] synthase 1 (TBXAS1, CYP5, CYP5A1)

Function

• synthesis of thromboxane A

Cofactor: heme-thiolate

Structure

• monomer
• belongs to the cytochrome P450 family

Compartment

endoplasmic reticulum membrane

Alternative splicing

named isoforms=4

Expression

• platelets, lung, kidney, spleen, macrophages & lung fibroblasts

Pathology

• defects in TBXAS1 are the cause of thromboxane synthetase deficiency
• defects in TBXAS1 are the cause of Ghosal hematodiaphyseal dysplasia

Notes

• uncertain whether Met-1 is the initiator
• an alternative upstream Met is found in primates
  • not found in other mammals

More general terms

• transmembrane 4 protein
• isomerase
• cytochrome P450
• human longevity protein

Additional terms

• cyclooxygenase cascade

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6916
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6916
• OMIM: https://mirror.omim.org/entry/231095
• OMIM: https://mirror.omim.org/entry/274180
• UniProt: http://www.uniprot.org/uniprot/P24557.html