vasohibin-1 (VASH1, KIAA1036, VASH)

Function

• angiogenesis inhibitor
• inhibits migration, proliferation & network formation by endothelial cells as well as angiogenesis
• inhibitory effect is selective to endothelial cells, does not affect the migration of smooth muscle cells or fibroblasts
• does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth & tumor angiogenesis
• acts in an autocrine manner
• inhibits artery neointimal formation & macrophage infiltration
• exhibits heparin-binding activity
• 2 major forms (42 & 36 kD) & 2 minor forms (32 & 27 kD)
• may be processed by proteolytic cleavage
• largest form (42 kD) seems to be secreted, the other major form (63 kD) seems to accumulate within cells or pericellular milieu
• polypeptide consisting of Met-77 to Arg-318 may correspond to the 27 kD form & that consisting of Met-77 to Val-365 may correspond to the 36 kD form
• ubiquitinated in vitro
• interacts with SVBP enhancing VASH1 solubility & secretion & prevents its ubiquitination

Structure

• belongs to the vasohibin family
• although probably secreted, it lacks a canonical signal sequence

Compartment

secreted

Alternative splicing

named isoforms=2

Expression

• preferentially expressed in endothelial cells
• highly expressed in fetal organs
• expressed in brain & placenta, & at lower level in heart & kidney
• induced by VEGF

Pathology

• abundant in microvessels endothelial cells of atherosclerotic lesions

More general terms

• secreted protein
• endogenous angiogenesis inhibitor
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22846
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:22846
• OMIM: https://mirror.omim.org/entry/609011
• UniProt: http://www.uniprot.org/uniprot/Q7L8A9.html