equilibrative nucleoside transporter 2 (equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter, equilibrative NBMPR-insensitive nucleoside transporter, nucleoside transporter EI-type, 36 kD nucleolar protein HNP36, 36 kD hydrophobic nucleolar protein, delayed-early response protein 12, solute carrier family 29 {nucleoside transporter} member 2, SLC29A2)

Function

• mediates equilibrative transport of purine, pyrimidine nucleosides & the purine base hypoxanthine
• less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep & draflazine

Structure

belongs to the SLC29A transporter family

Compartment

• isoform 1: cell membrane
• isoform 2: nucleus membrane

Alternative splicing

named isoforms=2

Expression

• expressed in placenta, brain, heart & ovarian tissues
• induced by platelet-derived growth factor (PDGF) & fibroblast growth factor (FGF)

More general terms

• transmembrane 11 protein
• nuclear protein
• solute carrier family 29 (SLC29, SLC29A)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3177
• OMIM: https://mirror.omim.org/entry/602110
• UniProt: http://www.uniprot.org/uniprot/Q14542.html