tumor suppressor candidate 3; Mg+2 uptake/transporter TUSC3; protein N33 (TUSC3, N33)

Function

• Mg+2 transporter
• role in N-glycosylation through its association with N-oligosaccharyl transferase
• weakly associates with the N-oligosaccharyl transferase (OST complex)

Structure

• belongs to the OST3/OST6 family
• contains 1 thioredoxin domain

Compartment

endoplasmic reticulum membrane

Alternative splicing

named isoforms=2

Expression

• expressed in most non-lymphoid cells & tissues, including prostate, lung, liver, colon, heart, kidney & pancreas

Pathology

• defects in TUSC3 are the cause of mental retardation autosomal recessive type 7

More general terms

• transmembrane 4e protein
• human longevity protein

Component of

• N-oligosaccharyl transferase (OST)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7991
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7991
• OMIM: https://mirror.omim.org/entry/601385
• OMIM: https://mirror.omim.org/entry/611093
• UniProt: http://www.uniprot.org/uniprot/Q13454.html