catenin alpha-2; alpha-catenin-related protein; alpha N-catenin (CTNNA2, CAPR)

Function

• may function as a linker between cadherin adhesion receptors & the cytoskeleton to regulate cell-cell adhesion & differentiation in the nervous system
• regulates morphological plasticity of synapses & cerebellar & hippocampal lamination during development
• functions in the control of startle modulation
• interacts with ZNF639

Structure

• belongs to the vinculin/alpha-catenin family

Compartment

• cytoplasm, cytoskeleton (putative)
• cell junction, adherens junction (putative)
• cell membrane
• peripheral membrane, cytoplasmic side (putative)
• cell projection, axon (putative)
• recruited to the nucleus upon ZNF639 overexpression

Alternative splicing

named isoforms=6

More general terms

• alpha catenin
• phosphoprotein
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1496
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1496
• OMIM: https://mirror.omim.org/entry/114025
• UniProt: http://www.uniprot.org/uniprot/P26232.html