desmoglein-1; cadherin family member 4; desmosomal glycoprotein 1; DG1; DGI; Pemphigus foliaceus antigen (DSG1, CDHF4)

Function

• component of intercellular desmosome junctions
• involved in the interaction of plaque proteins & intermediate filaments mediating cell-cell adhesion

Structure

• Ca+2 may be bound by the cadherin-like repeats
• contains 4 cadherin domains

Compartment

• cell membrane; single-pass type 1 membrane protein (putative)
• cell junction, desmosome

Expression

epidermis, tongue, tonsil & esophagus

Pathology

• defects in DSG1 are the cause of palmoplantar keratoderma striate type 1

More general terms

• desmoglein (desmosomal glycoprotein)
• phosphoprotein
• human longevity protein

Additional terms

• pemphigus foliaceus

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1828
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1828
• OMIM: https://mirror.omim.org/entry/125670
• OMIM: https://mirror.omim.org/entry/148700
• UniProt: http://www.uniprot.org/uniprot/Q02413.html