SH2 domain-containing protein 4A; protein SH(2)A; protein phosphatase 1 regulatory subunit 38 (SH2D4A, PPP1R38, SH2A)

Function

• inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG & repressing estrogen-induced proliferation
• may play a role in T-cell development & function
• interacts with ESR1

Structure

contains 1 SH2 domain

Compartment

• cytoplasm
• located at podocyte foot processes (putative)

Alternative splicing

named isoforms=2

Expression

ubiquitously expressed

Pathology

• aberrantly expressed in some cancers

More general terms

• SH2 domain-containing protein
• phosphoprotein
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=63898
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:63898
• OMIM: https://mirror.omim.org/entry/614968
• UniProt: http://www.uniprot.org/uniprot/Q9H788.html