killer cell lectin-like receptor subfamily F member 1; lectin-like receptor F1; activating coreceptor NKp80; C-type lectin domain family 5 member C (KLRF1, CLEC5C, ML)

Function

• role in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts

Structure

• homodimer
• contains 1 C-type lectin domain

Compartment

membrane

Alternative splicing

named isoforms=4

Expression

• strongly expressed in peripheral blood leukocytes & spleen,
• weaker expression in lymph node & adult liver
• no expression in bone marrow, thymus, & fetal liver
• not expressed in brain, heart, placenta, lung, kidney, skeletal muscle, & pancreas
• within peripheral blood leukocyte & immunocyte cell lines, expression is predominant in NK cells but also expressed in monocytes

More general terms

• killer cell lectin like receptor
• glycoprotein
• human longevity protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5134
• OMIM: https://mirror.omim.org/entry/605029
• UniProt: http://www.uniprot.org/uniprot/Q9NZS2.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51348