protein BTG3; BTG family member 3; protein Tob5; abundant in neuroepithelium area protein (BTG3, ANA, TOB5)

Function

• overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase

Structure

• belongs to the BTG family

Alternative splicing

named isoforms=2

Expression

• ubiquitous
• high expression in the ventricular zone of the developing central nervous system
• high expression in ovary, testis, prostate, thymus & lung
• expression is cell cycle dependent with the highest levels at the end of G1 phase, peaking at the G1-S transition

More general terms

• anti-oncoprotein (tumor suppressor protein)
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10950
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10950
• OMIM: https://mirror.omim.org/entry/605674
• UniProt: http://www.uniprot.org/uniprot/Q14201.html