LIM/homeodomain protein LHX1B; LIM homeobox transcription factor 1 beta; LIM/homeobox protein 1.2; LMX-1.2 (LMX1B)

Function

• essential for the specification of dorsal limb fate at both the zeugopodal & autopodal levels

Structure

• contains 1 homeobox DNA-binding domain
• contains 2 LIM Zn+2-binding domains

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

Expression

• expressed in most tissues
• highest levels in testis, thyroid, duodenum, skeletal muscle, & pancreatic islets

Pathology

• defects in LMX1B are the cause of nail-patella syndrome

More general terms

• LIM/homeodomain protein
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4010
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4010
• OMIM: https://mirror.omim.org/entry/161200
• OMIM: https://mirror.omim.org/entry/602575
• UniProt: http://www.uniprot.org/uniprot/O60663.html