carbohydrate sulfotransferase 11; chondroitin 4-O-sulfotransferase 1; chondroitin 4-sulfotransferase 1; C4S-1; C4ST-1; C4ST1 (CHST11)

Function

• catalyzes transfer of sulfate to position 4 of the N-acetylgalactosamine (galNAc) residue of chondroitin to form chondroitin-4-sufate
• can also sulfate galactose residues in desulfated dermatan sulfate
• preferentially sulfates GlcA->galNAc > IdoA->galNAc
• does not form 4,6-di-O-sulfated galNAc when chondroitin sulfate C is used as an acceptor

3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate

Kinetic parameters:

• KM=0.5 uM for PAPS
• KM=2.1 mM for chondroitin

Structure

• N-glycosylation required for activity & stability
• belongs to the sulfotransferase 2 family

Compartment

• Golgi membrane
  • single-pass type 2 membrane protein (putative)

Alternative splicing

named isoforms=2

Expression

• widely expressed
• highly expressed in spleen, thymus, bone marrow, peripheral blood leukocytes, lymph node, heart, brain, lung & placenta

Pathology

• chromosomal translocation t(12;14)(q23;q32) involving CHST11 with IgH is found in B-cell chronic lymphocytic leukemias

More general terms

• carbohydrate sulfotransferase (CHST)
• membrane protein
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=50515
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:50515
• OMIM: https://mirror.omim.org/entry/610128
• UniProt: http://www.uniprot.org/uniprot/Q9NPF2.html