semaphorin-6A; semaphorin VIA; sema VIA; semaphorin-6A-1; SEMA6A-1 (SEMA6A, KIAA1368, SEMAQ)

Function

• cell surface receptor for PLXNA2
• role in cell-cell signaling
• required for normal granule cell migration in the developing cerebellum
• promotes reorganization of the actin cytoskeleton
• role in axon guidance in the developing CNS
• can act as repulsive axon guidance cue
• repulsive action towards migrating granular neurons
• may play a role in channeling sympathetic axons into the sympathetic chains & controlling the temporal sequence of sympathetic target innervation
• active as a homodimer or oligomer
• the SEMA6A homodimer interacts with a PLXNA2 homodimer, giving rise to a heterotetramer (putative)
• interacts with EVL

Structure

• belongs to the semaphorin family
• contains 1 PSI domain
• contains 1 sema domain

Compartment

• plasma membrane; single-pass type 1 membrane protein

Alternative splicing

named isoforms=2

More general terms

• membrane protein
• glycoprotein
• semaphorin or semaphorin/collapsin family protein
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57556
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57556
• OMIM: https://mirror.omim.org/entry/605885
• UniProt: http://www.uniprot.org/uniprot/Q9H2E6.html