plexin-A2; Semaphorin receptor OCT (PLXNA2, KIAA0463, OCT, PLXN2, UNQ209/PRO235)

Function

• coreceptor for SEMA3A
• signaling by class 3 semaphorins*
• remodelling of cytoskeleton
• axon guidance
• invasive growth
• cell migration
• interacts with NRP1, NRP2

* class 3 semaphorins bind to a complex composed of a neuropilin & a plexin. The plexin modulates affinity of the complex for specific semaphorins

Structure

• belongs to the plexin family
• contains 4 IPT/TIG domains
• contains 1 Sema domain

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

detected in fetal brain

More general terms

• plexin A
• glycoprotein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5362
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5362
• OMIM: https://mirror.omim.org/entry/601054
• UniProt: http://www.uniprot.org/uniprot/O75051.html