Mn+2 superoxide dismutase (SOD-2, Mn-SOD, SOD2)

Function

• destroys O2- radicals which are normally produced within cells & which are toxic to biological systems
• acetylation at Lys-122 decreases enzymatic activity
• deacetylated by SIRT3 upon exposure to ionizing radiation or after long fasting (putative)
• nitrated under oxidative stress
  • nitration coupled with oxidation inhibits the catalytic activity

2 O2- + 2 H+ = O2 + H2O2

Cofactor: binds 1 Mn+2 per subunit

Structure

• homotetramer
• belongs to the iron/Mn+2 superoxide dismutase family

Compartment

mitochondria matrix

Alternative splicing

named isoforms=4

Expression

• expression is regulated by KRIT1

Pathology

• genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes mellitus

More general terms

• superoxide dismutase
• mitochondrial protein
• oligomerizing protein
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6648
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6648
• OMIM: https://mirror.omim.org/entry/147460
• OMIM: https://mirror.omim.org/entry/612634
• UniProt: http://www.uniprot.org/uniprot/P04179.html