F-box-like/WD repeat-containing protein TBL1XR1; nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1-related protein 1; transducin beta-like 1X-related protein 1 (TBL1XR1, IRA1, TBLR1)

Function

• F-box-like protein involved in recruitment of the ubiquitin/19S proteasome complex to nuclear receptor- regulated transcription units
• role in transcription activation mediated by nuclear receptors
• component of the N-cor corepressor complex that mediates recruitment of the 19S proteasome complex, leading to the subsequent proteosomal degradation of N-cor complex
• phosphorylated upon DNA damage, probably by ATM or ATR
• probable component of some E3 ubiquitin ligase complex
• interacts with histones H2B & H4

Structure

• the F-box-like domain is related to the F-box domain, & apparently displays the same function as component of ubiquitin E3 ligase complexes (putative)
• belongs to the WD repeat EBI family
• contains 1 F-box-like domain
• contains 1 LisH domain
• contains 8 WD repeats

Compartment

nucleus (probable)

Expression

ubiquitous

More general terms

• F-box & WD-repeat protein
• phosphoprotein
• human longevity protein

Component of

• N-cor repressor complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79718
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79718
• OMIM: https://mirror.omim.org/entry/608628
• UniProt: http://www.uniprot.org/uniprot/Q9BZK7.html