hypoxia induced genes

Introduction

Genes induced by hypoxia regulate various processes including:

• oxygen transport & iron metabolism
  • ceruloplasmin
  • erythropoietin
  • ferritin light chain
  • heme oxygenase 1
  • transferrin/transferrin receptor

• angiogenesis
  • adrenomedullin
  • angiopoietin 2
  • cyclooxygenase 2
  • endothelin 1 & endothelin 2
  • fibroblast growth factor 3
  • hepatocyte growth factor
  • histone deacetylase
  • monocyte chemotactic protein 1
  • nitric oxide synthase
  • osteopontin
  • placental growth factor
  • tie 2 (angiopoietin receptor)
  • transforming growth factor alpha
  • transforming growth factor beta (1,2,3)
  • vascular endothelial growth factor (VEGF) A
  • VEGF receptor 1

• transcription factors
  • annexin V
  • bcl2-interacting killer (BIK)
  • cyclin G2
  • differentiated embryo chondrocyte expressed gene 1 (DEC1)
  • fos
  • jun
  • heat shock factor
  • hypoxia inducible factor (HIF) -1 alpha, -2 alpha
  • insulin like growth factor binding protein 1,2,3
  • p27kip1
  • lipocortin
  • NF kappa B
  • NIX (BCL2/adenovirus E1B 19-kD protein-interacting protein 3-like)
  • transgelin
  • transglutaminase 2
  • p21WAF1

• growth factors/cytokines
  • IGF 2
  • interleukin 6/8
  • intestinal trefoil factor
  • macrophage inhibitory factor
  • platelet derived growth factor
  • staniocalcin

• glycolysis/glucose uptake
  • aldolase A
  • enolase 1
  • glucose transporter-1/3
  • glyceraldehyde-3-phosphate dehydrogenase
  • hexokinase-1/2
  • lactate dehydrogenase A
  • phosphofructokinase C
  • phosphofructokinase L
  • phosphoglycerate kinase 1
  • pyruvate kinase M

• stress response
  • thioredoxin
  • 150 kDa oxygen-regulated protein
  • GADD153 (growth arrest and DNA damage inducible-153)
  • DNA-(apurinic or apyrimidinic site) lyase

• neurotransmitter production
  • tyrosine hydroxylase
  • alpha adrenergic receptor

• metabolism
  • acetoacetyl CoA thiolase
  • adenylate kinase 3

• cell adhesion
  • CD99
  • neural cell adhesion molecule L1
  • integrin alpha

• extracellular matrix
  • collagen 5 alpha-1
  • matrixin 13
  • proline-4-hydroxylase

• coagulation
  • tissue factor
  • plasminogen activator inhibitor 1
  • urokinase receptor

• cytoskeleton
  • vimentin

More general terms

• gene