C-C motif chemokine 2; HC11; monocyte chemoattractant protein 1; monocyte chemotactic & activating factor; MCAF; monocyte chemotactic protein 1; MCP-1; monocyte secretory protein JE; small-inducible cytokine A2 (CCL2, MCP1, SCYA2)
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Function
- chemotactic factor
- chemotactic for monocytes & basophils
- not chemotactic for neutrophils or eosinophils
- augments monocyte anti-tumor activity
- chemotactic for astrocytes in vitro[5]
- processing at the N-terminus can regulate receptor & target cell selectivity
- deletion of the N-terminal residue converts it from an activator of basophils to an eosinophil chemoattractant
- binds to CCR2 & CCR4
- tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans
Structure
- monomer or homodimer; in equilibrium
- belongs to the intercrine beta (chemokine CC) family
Compartment
Pathology
- implicated in the pathogenesis of diseases characterized by monocytic infiltrates, including
- psoriasis
- rheumatoid arthritis
- atherosclerosis
- may be involved in recruitment of monocytes into the arterial wall during atherosclerosis
Polymorphism
- genetic variations in CCL2 determine Mycobacterium tuberculosis susceptibility [MIM:607948]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P13500.html
- ↑ Herschman HR Extracellular signals, transcriptional responses and cellular specificity TIBS 14:455 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2696174
- ↑ Henderson B & Blake S Therapeutic potential of cytokine manipulation TIPS 13:145 1992 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1589908
- ↑ Ross R The pathogenesis of atherosclerosis Nature 362:801 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8479518
- ↑ 5.0 5.1 Wyss-Coray T et al, Adult mouse astrocytes degrade amyloid beta in vitro and in situ. Nature Med March 2003, 9:453 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12612547
- ↑ Wikipedia; Note: CCL2 entry http://en.wikipedia.org/wiki/CCL2
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/scya2/