fibroblast growth factor 3; FGF-3; heparin-binding growth factor 3; HBGF-3; proto-oncogene protein int-2 (FGF3, INT2)

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^[1]^[2]^[3]

Function

role in the regulation of embryonic development, cell proliferation, & cell differentiation
required for normal ear development
interacts with FGFR1 & FGFR2
affinity between fibroblast growth factors (FGFs) & their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors

Structure

belongs to the heparin-binding growth factors family

Compartment

secreted (putative)

Pathology

defects in FGF3 are a cause of deafness with labyrinthine aplasia, microtia & microdontia

Genetics

product of int-2 proto-oncogene^[1]
FGF-3 is suggested to be a viral integration product^[2]

More general terms

References

↑ ^{Jump up to: 1.0} ^1.1 Cross M, Dexter TM. Growth factors in development, transformation, and tumorigenesis. Cell. 1991 Jan 25;64(2):271-80. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1988148
↑ ^{Jump up to: 2.0} ^2.1 Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2248
↑ UniProt http://www.uniprot.org/uniprot/P11487.html

Database

Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2248
Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2248
OMIM: https://mirror.omim.org/entry/164950
OMIM: https://mirror.omim.org/entry/610706
UniProt: http://www.uniprot.org/uniprot/P11487.html

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