fibroblast growth factor 3; FGF-3; heparin-binding growth factor 3; HBGF-3; proto-oncogene protein int-2 (FGF3, INT2)

Function

• role in the regulation of embryonic development, cell proliferation, & cell differentiation
• required for normal ear development
• interacts with FGFR1 & FGFR2
• affinity between fibroblast growth factors (FGFs) & their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors

Structure

• belongs to the heparin-binding growth factors family

Compartment

secreted (putative)

Pathology

• defects in FGF3 are a cause of deafness with labyrinthine aplasia, microtia & microdontia

Genetics

• product of int-2 proto-oncogene
• FGF-3 is suggested to be a viral integration product

More general terms

• fibroblast growth factor
• proto oncogene protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2248
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2248
• OMIM: https://mirror.omim.org/entry/164950
• OMIM: https://mirror.omim.org/entry/610706
• UniProt: http://www.uniprot.org/uniprot/P11487.html