annexin A5, annexin V, endonexin-2, lipocortin-5, vascular anticoagulant alpha (VAC-alpha), anchorin-C2, thromboplastin inhibitor, calphobindin-1, placental anticoagulant protein-1 (PAP-I)
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Function
- anticoagulant protein
- acts as an indirect inhibitor of thromboplastin
- binds ATRX & EIF5B (putative)
Structure
- monomer
- a pair of annexin repeats may form one binding site for Ca+2 & phospholipid
- belongs to the annexin family
- contains 4 annexin repeats
- 3D structure described in[2]
- almost entirely alpha-helical
- each of the 4 repeats is folded into a compact domain of similar structure
Notes
- independently sequenced by at least 7 groups under different names
More general terms
References
- ↑ Rojas E, Pollard HB, Haigler HT, Parra C, Burns AL. Calcium-activated endonexin II forms calcium channels across acidic phospholipid bilayer membranes. J Biol Chem. 1990 Dec 5;265(34):21207-15. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2174439
- ↑ 2.0 2.1 Huber R, Berendes R, Burger A, Luecke H, Karshikov A. Annexin V-crystal structure and its implications on function. Behring Inst Mitt. 1992 Apr;(91):107-25. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1388018
- ↑ UniProt http://www.uniprot.org/uniprot/P08758.html
- ↑ R&D systems' cytokine source book: annexin V http://www.rndsystems.com/molecule_detail.aspx?m=1063