phosphoglycerate kinase 1 (primer recognition protein 2, PRP 2, cell migration-inducing gene 10 protein, PGK1, PGKA, MIG10, OK/SW-cl110)

Function

• glycolytic enzyme
• polymerase alpha cofactor protein (primer recognition protein)
• carbohydrate degradation; glycolysis
• pyruvate from D-glyceraldehyde 3-phosphate, step 2/5

ATP + 3-phospho-D-glycerate <--> ADP + 3-phospho-D-glyceroyl phosphate

Structure

• monomer
• belongs to the phosphoglycerate kinase family

Compartment

cytoplasm

Pathology

• defects in PGK1 are generally associated with chronic hemolytic anemia although it can be accompanied by either mental retardation or muscular disease (rhabdomyolysis)

More general terms

• phosphoglycerate kinase

Database

• OMIM: https://mirror.omim.org/entry/311800
• UniProt: http://www.uniprot.org/uniprot/P00558.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5230