glyceraldehyde-3-phosphate dehydrogenase (GAPDH, GAPD, CDABP0047, OK/SW-cl12)

Function

• role in gluconeogenesis & the glycolytic pathway
• role in membrane trafficking in the early secretory pathway
• appears to mediate apoptosis
• cytotoxic stimuli lead to binding of GAPDH to Siah1 via release of nitric oxide.
• the GAPDH-Siah1 complex translocates from cytoplasm to nucleus in a process ultimately leading to cell death
• binds PRKCI

Structure

• homotetramer.
• belongs to the glyceraldehyde-3-phosphate dehydrogenase family

Compartment

• cytoplasm,
• postnuclear & perinuclear regions
• membrane

More general terms

• aldehyde oxidoreductase
• dehydrogenase

More specific terms

• testis glyceraldehyde-3-phosphate dehydrogenase (GAPDHS, GAPDH-2, GAPD2, GAPDH2, GAPDS, HSD35, HSD-35)

Additional terms

• gluconeogenesis
• glycolytic pathway (glycolysis, Embden Myerhof pathway)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2597
• UniProt: http://www.uniprot.org/uniprot/P04406.html
• OMIM: https://mirror.omim.org/entry/138400