testis glyceraldehyde-3-phosphate dehydrogenase (GAPDHS, GAPDH-2, GAPD2, GAPDH2, GAPDS, HSD35, HSD-35)

Function

• may play an important role in regulating the switch between different pathways for energy production during spermiogenesis & in the spermatozoon
• required for sperm motility & male fertility (putative)
• carbohydrate degradation; glycolysis
• pyruvate from D-glyceraldehyde 3-phosphate: step 1/5

D-glyceraldehyde 3-phosphate + phosphate + NAD+
               <-->
3-phospho-D-glyceroyl phosphate + NADH

Structure

• homotetramer (putative)
• belongs to the glyceraldehyde-3-phosphate dehydrogenase family

Compartment

cytoplasm (putative)

Expression

testis specific

More general terms

• glyceraldehyde-3-phosphate dehydrogenase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2633
• UniProt: http://www.uniprot.org/uniprot/O14556.html