vascular endothelial growth factor receptor 1; VEGFR-1; vascular permeability factor receptor; tyrosine-protein kinase receptor FLT; Flt-1; tyrosine-protein kinase FRT; Fms-like tyrosine kinase 1 (FLT1, FLT, FRT)

Function

• receptor for VEGF, VEGFB & PGF
• has a tyrosine-protein kinase activity
• the VEGF-kinase ligand/receptor signaling system plays a role in vascular development & regulation of vascular permeability
• isoform SFlt1 may have an inhibitory role in angiogenesis
• interacts in vitro with various phosphotyrosine-binding proteins, including: PLC-gammas, PTPN11, GRB2, CRK & NCK1
• Flt1 & Flk1 bind VEGF with high affinity & are required for embryonic & definitive hematopoiesis

Structure

• belongs to the protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily
• contains 7 Ig-like C2-type domain (immunoglobulin-like)
• contains 1 protein kinase domain

Compartment

• isoform Flt1: cell membrane
• isoform sFlt1: secreted

Alternative splicing

named isoforms=2

Additional isoforms seem to exist

Expression

• mostly in normal lung, but also in placenta, liver, kidney, heart & brain
• specifically expressed in most vascular endothelial cells
• also expressed in peripheral blood monocytes
• not expressed in tumor cell lines
• isoform sFlt1 is strongly expressed in placenta

Pathology

• plasma levels of soluble fms-like tyrosine kinase 1 are increased in women with pre-eclampsia

Laboratory

• soluble fms-like tyrosine kinase-1 in serum

More general terms

• vascular endothelial growth factor [VEGF] receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2321
• OMIM: https://mirror.omim.org/entry/165070
• UniProt: http://www.uniprot.org/uniprot/P17948.html