vascular endothelial growth factor B; VEGF-B; VEGF-related factor; VRF (VEGFB, VRF)

Function

• growth factor for endothelial cells
• VEGF-B167 binds heparin & neuropilin-1 whereas binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis

Structure

• homodimer; disulfide-linked
• can also form heterodimer with other VEGFs
• VEGF-B186 is O-glycosylated (putative)
• belongs to the PDGF/VEGF growth factor family

Compartment

• secreted
• secreted but remains associated to cells or to the extracellular matrix unless released by heparin

Alternative splicing

• named isoforms=2; VEGF-B186, VEGF-B167;
• additional isoforms seem to exist

Expression

• expressed in all tissues except liver
• highest levels found in heart, skeletal muscle & pancreas

More general terms

• vascular endothelial growth factor family protein (VEGF family)

Additional terms

• vascular endothelial growth factor-A; vascular permeability factor (VEGFA, VEGF, VPF)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7423
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7423
• OMIM: https://mirror.omim.org/entry/601398
• UniProt: http://www.uniprot.org/uniprot/P49765.html