ferritin light chain; ferritin L subunit (FTL, FTL1)

Function

• light chain of ferritin

Structure

• belongs to the ferritin family
• contains 1 ferritin-like diiron domain

Pathology

• defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (mutations in the iron responsive element (IRE) of the FTL gene)
• defects in FTL are the cause of neuroferritinopathy

Comparative biology

• in aging mice, higher levels of hippocampal FTL1* results in reduces neuronal connectivity & memory decline
  • higher levels of hippocampal FTL1* in young mice results in look function & behavior more resembling older mice
  • reducing hippocampal levels of FTL1 in old mice with NADH supplementation enhances neural connectivity & improves performance on memory tests
  • NADH supplementation in human is safe, but does not seem to have anti-aging effects

* FTL1 is a mouse-specific ferritin light chain

• no corresponding human gene or protein
• there is a mouse FTL2

More general terms

• protein subunit

Component of

• ferritin

Database

• UniProt: http://www.uniprot.org/uniprot/P02792.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2512
• OMIM: https://mirror.omim.org/entry/134790
• OMIM: https://mirror.omim.org/entry/600886
• OMIM: https://mirror.omim.org/entry/606159