trefoil factor 3; intestinal trefoil factor; hITF; polypeptide P1.B; hP1.B (TFF3, ITF, TFI)

Function

• role in maintenance & repair of the intestinal mucosa
• promotes mobility of epithelial cells in healing processes (motogen)

Structure

• monomer. homodimer; disulfide-linked
• contains 1 P-type (trefoil) domain

Compartment

• secreted, extracellular space, extracellular matrix
• apical lamina

Expression

• expressed in goblet cells of the intestines & colon (at protein level)
• expressed by goblet cells of intestinal epithelia
• expressed in uterus

More general terms

• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7033
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7033
• OMIM: https://mirror.omim.org/entry/600633
• UniProt: http://www.uniprot.org/uniprot/Q07654.html