aldolase-A (muscle-type aldolase, lung cancer antigen NY-LU-1, ALDOA, ALDA)

Function

• carbohydrate degradation; glycolysis
• D-glyceraldehyde 3-phosphate & glycerone phosphate from D-glucose: step 4/4
• 50-fold greater activity with fructose 1,6-bisphosphate than fructose-1-phosphate.

D-fructose 1,6-bisphosphate
          <-->
glycerone phosphate + D-glyceraldehyde 3-phosphate

Structure

• homotetramer
• belongs to the class 1 fructose-bisphosphate aldolase family

Pathology

• defects in ALDOA are a cause of hemolytic anemia

More general terms

• fructose-1,6 diphosphate aldolase
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P04075.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:226
• OMIM: https://mirror.omim.org/entry/103850
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=226