fructose-1,6 diphosphate aldolase or fructose diphosphate aldolase

Classification

• in vertebrates, 3 forms of are found
  • aldolase-A in muscle
  • aldolase-B in liver
  • aldolase-C in brain

Function

• ubiquitous glycolytic enzyme
• splits D-fructose-1,6-diphosphate to: D-glyceraldehyde-3-phosphate + dihydroxyacetone-phosphate

Structure

• tetramer

Expression

• the most common isozyme pattern consists of varying proportions of a 5-membered set in which 2 members correspond to aldolase A & aldolase B homotetramers
• in brain, aldolase-C is expressed so that tetramers of aldolase-A, aldolase-C & 3 aldolase-A/C heterotetramers are found

Genetics

• subunits determined by 3 separate gene loci
• only 2 of these loci, those producing Aldolase-A & aldolase-B appear to be active simultaneously in most tissues

Comparative biology

• class-II aldolases found mainly in prokaryotes & fungi, are homodimeric enzymes requiring a divalent metal ion (generally Zn+2) for their activity

More general terms

• aldehyde lyase (aldolase)
• oligomerizing protein
• glycolytic enzyme

More specific terms

• aldolase-A (muscle-type aldolase, lung cancer antigen NY-LU-1, ALDOA, ALDA)
• aldolase-B (liver-type aldolase, ALDOB, ALDB)
• aldolase-C (brain-type aldolase, ALDOC, ALDC)

Additional terms

• fructose-1,6-diphosphate aldolase in serum
• gluconeogenesis
• glycolytic pathway (glycolysis, Embden Myerhof pathway)