aldolase-B (liver-type aldolase, ALDOB, ALDB)

Function

• carbohydrate degradation; glycolysis
• D-glyceraldehyde 3-phosphate & glycerone phosphate from D-glucose: step 4/4
• allegedly, least specific for D-fructose 1,6-bisphosphate vs fructose-1-phosphate of aldolases ALDOA, ALDOB, ALDOC

D-fructose 1,6-bisphosphate
       <-->
glycerone phosphate + D-glyceraldehyde 3-phosphate

Kinetic parameters:

• KM=1.6 uM for fructose 1,6-bisphosphate
• KM=2.3 mM for fructose 1-phosphate

Structure

• homotetramer
• belongs to the class I fructose-bisphosphate aldolase family

Expression

• present in kidney & intestine as well as liver

Pathology

• defects in ALDOB are the cause of hereditary fructose intolerance

More general terms

• fructose-1,6 diphosphate aldolase
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P05062.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:229
• OMIM: https://mirror.omim.org/entry/229600
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=229